![]() ![]() DILI cases and non-DILI acute liver injury controls had similar demographics, clinical features and outcomes. DILI patients (mean age 56 years), 57% women, 60% with jaundice and 3.6% had pre-existing liver disease. Results: Of 446 adjudicated patients, 246 DILI patients and 100 had acute liver injury due to other aetiologies, mostly autoimmune hepatitis (n = 42) and viral hepatitis (n = 34). DILI cases or non-DILI acute liver injury controls following causality assessment were enrolled. Methods: Patients with suspected DILI were prospectively enrolled in the United Kingdom, Spain, Germany, Switzerland, Portugal and Iceland, 2016-2021. The design of a prospective European DILI registry, clinical features and short-term outcomes of the cases and controls is reported. Copy Abstractīackground & aims: No multi-national prospective study of drug-induced liver injury (DILI) has originated in Europe. A new framework for advancing in drug-induced liver injury research. Björnsson, Einar S Stephens, Camilla Atallah, Edmond Robles‐Diaz, Mercedes Alvarez‐Alvarez, Ismael Gerbes, Alexander Weber, Sabine Stirnimann, Guido Kullak‐Ublick, Gerd Cortez‐Pinto, Helena Grove, Jane I Lucena, M Isabel Andrade, Raul J Aithal, Guruprasad P (2023).
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